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May 9, 2023Diabetes Research and Clinical PracticeOpen Access

Cardiac autonomic neuropathy in patients with diabetes was associated with increased glycemic variability, including higher CONGA (8.42 vs 6.68; P=0.024) and greater time in hyperglycemia.

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Why the study?

Cardiac autonomic neuropathy has been suggested to be associated with hypoglycemia and impaired hypoglycemia unawareness, prompting assessment of its relationship with extensive glucose variability measures in diabetes.

Is cardiovascular autonomic neuropathy associated with increased glycemic variability in patients with diabetes?

Population

40 participants with type 1 and type 2 diabetes

Comparison

Participants with CAN vs without CAN

Key result

Cardiac autonomic neuropathy in patients with diabetes was associated with increased glycemic variability, including higher CONGA (8.42 vs 6.68; P=0.024) and greater time in hyperglycemia.

Authors

HGHoda GadEEEinas ElgassimIMIbrahim Mohammed

Discussion

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Member takes

Overview

Hypothesis-generating for CAN-glycemic variability links in diabetes; prospective studies needed before clinical adoption.

Study Design

Type

Cross-Sectional (n=40)

Structured PICO

Is cardiovascular autonomic neuropathy associated with increased glycemic variability in patients with diabetes?

P
Population
40 patients with type 1 and type 2 diabetes (mean age 40.7 years) who underwent continuous glucose monitoring and cardiovascular autonomic reflex testing.
E
Exposure
Presence of cardiovascular autonomic neuropathy (CAN)
C
Comparator
Absence of cardiovascular autonomic neuropathy (CAN)
O
Outcome
Measures of glucose variability (GV) and the extent of hyperglycemia and hypoglycemia assessed by continuous glucose monitoring (CGM)surrogate

Main Result

Absolute Event Rate: 8.42% vs 6.68%

p-value: p=0.024

Cardiovascular autonomic neuropathy in patients with diabetes is associated with increased glycemic variability driven primarily by greater time spent in hyperglycemia rather than hypoglycemia.

Cite This Study

Gad et al. (2023) conducted a cross-sectional in Type 1 and Type 2 diabetes (n=40). Cardiac autonomic neuropathy vs. No cardiac autonomic neuropathy was evaluated on Continuous overall net glycemic action (CONGA) (p=0.024). Cardiac autonomic neuropathy in patients with diabetes was associated with increased glycemic variability, including higher CONGA (8.42 vs 6.68; P=0.024) and greater time in hyperglycemia.

synapsesocial.com/papers/6a7c6cf499c6d6845826c07ehttps://doi.org/10.1016/j.diabres.2023.110670
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular Autonomic Neuropathy Is Associated With Increased Glucose Variability in People With Type 1 Diabetes2022 · 11 citations
  2. 2The association between glycemic variability and diabetic cardiovascular autonomic neuropathy in patients with type 2 diabetes2015 · 113 citations
  3. 3The relationship between Cardiac Autonomic Dysfunction and Glycemic Variability in Pediatric Patients with Type 1 Diabetes Mellitus2023
  4. 4Continuous glucose monitoring defined glucose variability is associated with cardiovascular autonomic neuropathy in type 1 diabetes2018 · 55 citations
  5. 5Cardiovascular Autonomic Neuropathy Predicts Higher HbA1c Variability in Subjects with Type 2 Diabetes Mellitus2018 · 13 citations