Why the study?
Is cardiovascular autonomic neuropathy associated with increased glucose variability in people with type 1 diabetes?
Population
48 participants with Type 1 Diabetes
Comparison
Cardiovascular autonomic neuropathy diagnosis vs Matched control subjects without cardiovascular…
Design
Case-control, blinded continuous glucose monitoring
Follow-up
10 days
Key result
Cardiovascular autonomic neuropathy in type 1 diabetes was associated with a 4.9% higher coefficient of variation in glucose levels (95% CI 1.0-8.7; P=0.014) compared to matched controls.
Authors
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CAN diagnosis may associate with higher GV in T1D; leaves open causality and clinical relevance pending prospective data.
Case-Control (n=48)
Is cardiovascular autonomic neuropathy associated with increased glucose variability in people with type 1 diabetes?
Mean Difference: 4.9 (95% CI 1–8.7)
p-value: p=0.014
Cardiovascular autonomic neuropathy is associated with significantly higher glucose variability in patients with type 1 diabetes.
Naaman et al. (2022) conducted a case-control in Type 1 diabetes (n=48). Cardiovascular autonomic neuropathy (CAN) vs. Matched control subjects without CAN was evaluated on Coefficient of variation (CV) of glucose (MD 4.9%, 95% CI 1.0-8.7, p=0.014). Cardiovascular autonomic neuropathy in type 1 diabetes was associated with a 4.9% higher coefficient of variation in glucose levels (95% CI 1.0-8.7; P=0.014) compared to matched controls.