Key result
Cardiovascular autonomic neuropathy in T1D is linked to ~5% higher glucose variability versus controls.
Why the study?
Autonomic dysfunction has previously been associated with increased glucose variability, but the association between cardiovascular autonomic neuropathy diagnosis and glucose variability in type 1 diabetes was investigated.
Is cardiovascular autonomic neuropathy associated with increased glucose variability in people with type 1 diabetes?
Case-Control (n=48)
Is cardiovascular autonomic neuropathy associated with increased glucose variability in people with type 1 diabetes?
Answers are grounded in this paper and cite their sources.
Cardiovascular autonomic neuropathy is associated with significantly higher glucose variability in patients with type 1 diabetes.
OBJECTIVE: We investigated the association between the cardiovascular autonomic neuropathy (CAN) diagnosis and glucose variability (GV) in type 1 diabetes (T1D), as autonomic dysfunction previously has been associated with increased GV. RESEARCH DESIGN AND METHODS: CAN was assessed by three recommended cardiovascular reflex tests (CARTs). Glucose metrics were obtained from 10-day blinded continuous glucose monitoring (CGM). Between-group differences in GV indices were assessed by regression analyses in 24 participants with T1D with CAN and 24 matched control subjects without CAN. RESULTS: The CAN diagnosis was associated with 4.9% (95% CI 1.0, 8.7) higher coefficient of variation (CV) (P = 0.014), 0.7 mmol/L (0.3, 1.1) higher SD (P = 0.002) of glucose, and 1.4 mmol/mol (0.0, 2.7) higher mean amplitude of glycemic excursions (P = 0.047). Lower measures of CARTs were associated with higher CV, SD, and time above range values. CONCLUSIONS: The CAN diagnosis associates with a significantly higher GV in T1D, despite a high prevalence of routine CGM use.
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Naaman et al. (2022) conducted a case-control in Type 1 diabetes (n=48). Cardiovascular autonomic neuropathy (CAN) vs. Matched control subjects without CAN was evaluated on Coefficient of variation (CV) of glucose (MD 4.9%, 95% CI 1.0-8.7, p=0.014). Cardiovascular autonomic neuropathy in type 1 diabetes was associated with a 4.9% higher coefficient of variation in glucose levels compared to matched controls.
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