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October 22, 2018Diabetes/Metabolism Research and Reviews

CGM-defined glycaemic variability, especially percent time in level 2 hypoglycaemia, was independently associated with cardiovascular autonomic neuropathy (present in 45.0% of patients).

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Why the study?

Is continuous glucose monitoring-defined glycemic variability associated with cardiovascular autonomic neuropathy in adults with type 1 diabetes?

Population

80 adults with type 1 diabetes who underwent 3-day continuous glucose monitoring and autonomic function…

Design

Cross-sectional

Key result

CGM-defined glycaemic variability, especially percent time in level 2 hypoglycaemia, was independently associated with cardiovascular autonomic neuropathy (present in 45.0% of patients).

Authors

JJJi Eun JunSLSeung‐Eun LeeYLYou‐Bin Lee

Discussion

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Member takes

Overview

May aid CAN risk stratification via CGM; hypothesis-generating and should not yet change practice.

Study Design

Type

Cross-Sectional (n=80)

Structured PICO

Is continuous glucose monitoring-defined glycemic variability associated with cardiovascular autonomic neuropathy in adults with type 1 diabetes?

P
Population
80 adults with type 1 diabetes who underwent 3-day continuous glucose monitoring and autonomic function tests within 3 months.
E
Exposure
Continuous glucose monitoring (CGM)-defined glycaemic variability (GV) parameters
O
Outcome
Cardiovascular autonomic neuropathy (CAN), defined as at least two abnormal parasympathetic tests or the presence of orthostatic hypotensionsurrogate

In adults with type 1 diabetes, continuous glucose monitoring-defined glycemic variability, particularly time spent in level 2 hypoglycemia, is independently associated with cardiovascular autonomic neuropathy.

Cite This Study

Jun et al. (2018) conducted a cross-sectional in Type 1 diabetes (n=80). Continuous glucose monitoring-defined glycaemic variability was evaluated on Cardiovascular autonomic neuropathy (CAN). CGM-defined glycaemic variability, especially percent time in level 2 hypoglycaemia, was independently associated with cardiovascular autonomic neuropathy (present in 45.0% of patients).

synapsesocial.com/papers/6a773f5b576efb0ddaf732cbhttps://doi.org/10.1002/dmrr.3092
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The association between glycemic variability and diabetic cardiovascular autonomic neuropathy in patients with type 2 diabetes2015 · 113 citations
  2. 2Cardiovascular Autonomic Neuropathy Is Associated With Increased Glucose Variability in People With Type 1 Diabetes2022 · 11 citations
  3. 3Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes2023 · 16 citations
  4. 4The relationship between glycaemic variability and cardiovascular autonomic dysfunction in patients with type 1 diabetes: A systematic review2020 · 26 citations
  5. 5The Association Between Continuous Glucose Monitoring-Derived Metrics and Cardiovascular Autonomic Neuropathy in Outpatients with Type 2 Diabetes2021 · 31 citations