December 1, 1985The Journal of Immunology
Antigen presentation by interferon-gamma-treated endothelial cells and fibroblasts: differential ability to function as antigen-presenting cells despite comparable Ia expression.
Authors
Discussion
Loading...
Member takes
Implication
Randomized trial examines antigen presentation abilities in endothelial cells and fibroblasts, suggesting differences in immune function.
Key Points
- The study investigates the impact of interferon-gamma on the antigen presenting ability of endothelial cells and fibroblasts.
- Examined HLA gene expression in endothelial cells and fibroblasts treated with interferon-gamma.
- Assessed their ability to stimulate allogeneic T4 cell DNA synthesis.
- Compared the effectiveness of fibroblasts and endothelial cells in antigen presentation.
- IFN-gamma-treated endothelial cells stimulated allogeneic T4 cell DNA synthesis effectively, while treated fibroblasts did not.
- Both cell types expressed HLA-DR, but fibroblasts were poor antigen-presenting cells despite some expression of class II MHC.
- Monocytes enhanced the ability of treated fibroblasts to stimulate T4 cells, which suggests alternative pathways for immune activation.
Cite This Study
Geppert et al. (1985) studied this question.