Population
In vitro biochemical model of actomyosin-ADP-Pi and thin filament proteins (actin-tropomyosin-troponin)
Comparison
Addition of calcium and/or rigor myosin-S1 vs Low calcium and without rigor myosin-S1
Design
Preclinical
Authors
Loading...
Challenges three-state thin filament model in vitro; leaves open relevance to cardiac contraction in vivo.
Calcium and myosin-S1 synergistically accelerate the rate of phosphate dissociation from actomyosin-ADP-Pi, requiring an additional step beyond the three-state model of thin filament regulation.
Heeley et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: