Population
Moloney murine leukemia virus (MoMuLV) particles and Kirsten sarcoma virus
Comparison
Viral protease mutation or cysteine array mutation vs Mature wild-type virions
Design
Preclinical
Authors
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Gag cleavage is required for dimeric RNA maturation in retroviruses; leaves open its utility as an antiviral target.
Maturation of dimeric RNA in released virus particles requires cleavage of the Gag precursor and an intact cysteine array in the nucleocapsid protein.
Fu et al. (1993) studied this question.
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