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March 1, 1977Journal of VirologyOpen Access

Low-molecular-weight RNAs of Moloney murine leukemia virus: identification of the primer for RNA-directed DNA synthesis

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Population

Moloney murine leukemia virus (M-MuLV) small RNAs

Comparison

Two-dimensional polyacrylamide gel electrophoresis vs Rous sarcoma virus

Design

Preclinical

Authors

GPGodefridus J. PetersUniversity of PisaFHFumio HaradaKyoto UniversityJDJ E DahlbergUniversity of Wisconsin–Madison

Discussion

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Implication

No immediate clinical implications for retroviral disease; leaves open generalizability of primer mechanisms beyond this in vitro model.

Structured PICO

P
Population
Moloney murine leukemia virus (M-MuLV) small RNAs
I
Intervention
Two-dimensional polyacrylamide gel electrophoresis
C
Comparator
Rous sarcoma virus
O
Outcome
Identification of the primer for RNA-directed DNA synthesis

Identified a cellular tRNA as the major primer for M-MuLV RNA-directed DNA synthesis in vitro.

Cite This Study

Peters et al. (1977) studied this question.

synapsesocial.com/papers/6a8327f728b8a62be99908bbhttps://doi.org/10.1128/jvi.21.3.1031-1041.1977
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Covalent Linkage Between Ribonucleic Acid Primer and Deoxyribonucleic Acid Product of the Avian Myeloblastosis Virus Deoxyribonucleic Acid Polymerase1972 · 58 citations
  2. 2Small RNAs of Rous Sarcoma Virus: Characterization by Two-Dimensional Polyacrylamide Gel Electrophoresis and Fingerprint Analysis1973 · 122 citations
  3. 3Transcription of DNA from the 70 S RNA of Rous Sarcoma Virus II. Structure of a 4 S RNA Primer1974 · 104 citations
  4. 4Characterization of the Low-Molecular-Weight RNAs Associated with the 70 S RNA of Rous Sarcoma Virus1973 · 92 citations
  5. 5Physical properties of Rous Sarcoma Virus RNA.1968 · 272 citations