April 1, 1993Cardiovascular Research

Cardiac protection by ischaemic preconditioning is not mediated by myocardial stunning

View Full Paper

Ask AI

Bookmark

Why the study?

Does restoring contractile function with dobutamine abolish the cardioprotective effect of ischaemic preconditioning in dogs?

Population

Dogs undergoing experimental coronary occlusion (n=34)

Comparison

Ischaemic preconditioning followed by… vs Untreated control, untreated preconditioning…

Design

Preclinical

Follow-up

4 days of reperfusion

Authors

MMMegumi MatsudaNara Medical University TCThomas G. CatenaDuke University RHRichard S. Vander HeideMarshfield Clinic

Discussion

Member takes

Implication

Dobutamine appears compatible with preserved preconditioning protection in this model; leaves open mechanistic role of stunning and clinical translation.

Structured PICO

Does restoring contractile function with dobutamine abolish the cardioprotective effect of ischaemic preconditioning in dogs?

Population

Dogs undergoing experimental coronary occlusion (n=34)

Intervention

Ischaemic preconditioning (four 5 min occlusions of the left anterior descending coronary artery, each separated by 5 min of reperfusion) followed by intravenous dobutamine infusion (average dose = 5 micrograms.kg-1.min-1) to restore systolic shortening to baseline, prior to 40 min of sustained ischaemia and 4 days of reperfusion

Comparator

Untreated control (normal saline), untreated preconditioning, and non-preconditioned control with dobutamine

Outcome

Histological infarct size as a percentage of the area at risksurrogate

Restoring postischaemic contractile function with dobutamine does not abolish the cardioprotective effect of ischaemic preconditioning, indicating that reduced contractile effort (myocardial stunning) is not required for protection.

Cite This Study

Matsuda et al. (1993) studied this question.

synapsesocial.com/papers/6a7209f7439bab0cabc3be19 https://doi.org/10.1093/cvr/27.4.585

Topics

Women and heart disease

View Full Paper

Ask AI

Bookmark

Implication

Dobutamine appears compatible with preserved preconditioning protection in this model; leaves open mechanistic role of stunning and clinical translation.

Cardiac protection by ischaemic preconditioning is not mediated by myocardial stunning

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Cardiac protection by ischaemic preconditioning is not mediated by myocardial stunning

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider