Why the study?
Does ischemic preconditioning limit infarct size through myocardial stunning in anesthetized open-chest rabbits?
Population
Anesthetized open-chest rabbits
Comparison
Ischemic preconditioning protocols before… vs No preconditioning before 30-minute ischemia
Design
Preclinical
Follow-up
Up to 72 hours of reperfusion
Authors
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Preconditioning limits infarct size independently of stunning in rabbits; challenges mechanistic hypotheses and leaves open clinical translation.
Does ischemic preconditioning limit infarct size through myocardial stunning in anesthetized open-chest rabbits?
Myocardial stunning does not correlate with the infarct size-limiting effect of ischemic preconditioning, suggesting it does not contribute to cardioprotection.
Miura et al. (1991) studied this question.
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