Why the study?
Is ApoE polymorphism associated with a paternal history of premature myocardial infarction and altered lipid profiles in European youths?
Population
1,894 youths aged 18-26 years from 14 universities across 11 European countries.
Comparison
ApoE polymorphism (epsilon 2, 3, and 4 alleles) vs Age- and sex-matched control subjects without…
Design
Case-control
Authors
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Supports genetic contribution to early MI heritability in youths; leaves open whether ApoE testing should guide prevention.
Is ApoE polymorphism associated with a paternal history of premature myocardial infarction and altered lipid profiles in European youths?
ApoE polymorphism, particularly the epsilon 4 allele, is significantly associated with a paternal history of premature myocardial infarction and atherogenic lipid profiles in European youths.
Tiret et al. (1994) studied this question.
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