December 1, 1989Circulation ResearchOpen Access

Multiple types of Ca2+ currents in single canine Purkinje cells.

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Population

Isolated single canine Purkinje cells (n=36) and ventricular cells (n=12)

Comparison

Electrophysiological characterization of… vs Comparison between Purkinje and ventricular…

Design

Preclinical

Authors

GTGea‐Ny TsengVirginia Commonwealth University PBPenelope A. BoydenElectrophysiology

Discussion

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Implication

Differential T-type contribution may influence Purkinje-related arrhythmias; leaves open targeted modulation pending human validation.

Structured PICO

Population

Isolated single canine Purkinje cells (n=36) and ventricular cells (n=12)

Intervention

Electrophysiological characterization of whole-cell Ca2+ channel currents using various pharmacological agents (tetrodotoxin, Mn2+, Ni2+, nisoldipine, isoproterenol, norepinephrine) and ion substitutions

Comparator

Comparison between Purkinje and ventricular cells, and baseline vs. drug exposure

Outcome

Presence, density, and pharmacological modulation of T-type and L-type Ca2+ channel currentssurrogate

Canine Purkinje cells possess both T and L-type calcium channels that are differentially modulated by catecholamines, unlike ventricular cells where L-type channels predominate.

Cite This Study

Tseng et al. (1989) studied this question.

synapsesocial.com/papers/6a720c4d75498292b70b4d91 https://doi.org/10.1161/01.res.65.6.1735

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Multiple types of Ca2+ currents in single canine Purkinje cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Multiple types of Ca2+ currents in single canine Purkinje cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider