What question did this study set out to answer?

To assess the relationship between carotid atherosclerosis, evaluated via carotid artery intima-media thickness (IMT), and coronary artery disease in individuals with type 2 diabetes.

August 1, 2002Diabetes Care

Coronary Artery Disease and Carotid Artery Intima-Media Thickness in Japanese Type 2 Diabetic Patients

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Why the study?

Is carotid intima-media thickness associated with the presence of coronary artery disease in Japanese type 2 diabetic patients?

Key Points

To assess the relationship between carotid atherosclerosis, evaluated via carotid artery intima-media thickness (IMT), and coronary artery disease in individuals with type 2 diabetes.
Enrolled 40 type 2 diabetic patients with angiographically confirmed coronary artery disease (CAD) and 40 diabetic outpatient controls without CAD from the same institution.
Measured carotid intima-media thickness bilaterally using B-mode ultrasonography and analyzed CAD associations using logistic regression.
Carotid IMT was significantly higher in diabetic patients with CAD than in diabetic controls (1.27 ± 0.07 vs. 1.03 ± 0.04 mm, P < 0.05), with multivariable logistic regression showing an association at P = 0.062.
Among patients with CAD, those who underwent coronary artery bypass grafting had significantly greater IMT than those who did not (1.47 ± 0.11 vs. 1.07 ± 0.07 mm, P < 0.05).

Structured PICO

Is carotid intima-media thickness associated with the presence of coronary artery disease in Japanese type 2 diabetic patients?

Population

80 Japanese nonobese subjects with type 2 diabetes (40 with coronary artery disease determined by coronary angiography, 40 diabetic outpatients without CAD).

Outcome

Carotid intima-media thickness (IMT) measured by B-mode ultrasonographysurrogate

Increased carotid intima-media thickness is associated with the presence of coronary artery disease in Japanese patients with type 2 diabetes, particularly those requiring coronary artery bypass grafting.

Discussion

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Implication

Does not support routine IMT use for CAD risk stratification in T2D; leaves open incremental value in Japanese cohorts.

Cite This Study

Mitsuhashi et al. (2002) studied this question.

synapsesocial.com/papers/6a720e98ce524a4339c5431c https://doi.org/10.2337/diacare.25.8.1308

Topics

Coronary artery disease

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Coronary Artery Disease and Carotid Artery Intima-Media Thickness in Japanese Type 2 Diabetic Patients

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Coronary Artery Disease and Carotid Artery Intima-Media Thickness in Japanese Type 2 Diabetic Patients

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider