What question did this study set out to answer?

To investigate the dialogue between the immune and neuroendocrine systems in Obese strain chickens, an animal model of spontaneous autoimmune thyroiditis analogous to Hashimoto thyroiditis.

September 1, 1987The Journal of Immunology

Disturbed immune-endocrine communication in autoimmune disease. Lack of corticosterone response to immune signals in obese strain chickens with spontaneous autoimmune thyroiditis.

View Full Paper

Ask AI

Bookmark

Authors

KSKonrad SchauensteinInstitute of Molecular Functional Materials RFR. FässlerMax Planck Institute of Biochemistry HDH. DietrichInnsbruck Medical University

Discussion

Member takes

Implication

Animal experiment demonstrates defective corticosterone elevation following immune challenge in Obese strain chickens, indicating impaired neuroendocrine-immune regulation in thyroid autoimmunity.

Key Points

To investigate the dialogue between the immune and neuroendocrine systems in Obese strain chickens, an animal model of spontaneous autoimmune thyroiditis analogous to Hashimoto thyroiditis.
Immunized 5-month-old Obese strain (OS) and Normal White Leghorn (NWL) chickens with sheep red blood cells and tracked daily serum corticosterone levels.
Administered single intravenous injections of concanavalin A-stimulated spleen cell conditioned medium (CM) to measure dose-dependent corticosterone spikes and peripheral blood lymphocyte proliferation.
NWL chickens showed marked serum corticosterone increases 3 to 4 days post-immunization, whereas OS chickens displayed no corticosterone elevation.
Intravenous injection of CM produced a transient corticosterone peak that was significantly lower in OS chickens compared to NWL controls, despite CM from both strains showing equivalent stimulatory capacity.
CM injection triggered a concurrent suppression of concanavalin A-induced lymphocyte proliferation in both strains, but this immunosuppression was significantly less pronounced in OS chickens.

Cite This Study

Schauenstein et al. (1987) studied this question.

synapsesocial.com/papers/6a720e99f44fa9f079dfaa61 https://doi.org/10.4049/jimmunol.139.6.1830

View Full Paper

Ask AI

Bookmark

Implication

Animal experiment demonstrates defective corticosterone elevation following immune challenge in Obese strain chickens, indicating impaired neuroendocrine-immune regulation in thyroid autoimmunity.

Disturbed immune-endocrine communication in autoimmune disease. Lack of corticosterone response to immune signals in obese strain chickens with spontaneous autoimmune thyroiditis.

Discussion

Member takes

Implication

Key Points

Cite This Study

Disturbed immune-endocrine communication in autoimmune disease. Lack of corticosterone response to immune signals in obese strain chickens with spontaneous autoimmune thyroiditis.

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider