What question did this study set out to answer?

To identify genetic interactions and buffering mechanisms that ensure phenotypic robustness during Caenorhabditis elegans posterior embryonic patterning.

April 11, 2005Genome biologyOpen Access

Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions

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Authors

LBL. Ryan BaughDuke University JWJoanne C. WenDuke University AHAndrew A. HillAuckland City Hospital

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Implication

Genetic screen reveals conserved compensatory transcription factor interactions and a core muscle module in Caenorhabditis elegans embryos, suggesting evolutionary conservation of embryonic gene...

Key Points

To identify genetic interactions and buffering mechanisms that ensure phenotypic robustness during Caenorhabditis elegans posterior embryonic patterning.
Screened for synthetic lethality by performing RNA interference on 22 posterior patterning genes across 15 mutant Caenorhabditis elegans strains.
Assessed functional interaction conservation in the related nematode Caenorhabditis briggsae and evaluated homology with vertebrate myogenic pathways.
Identified conserved compensatory interaction between the homologous T-box transcription factors tbx-8 and tbx-9 across both C. elegans and C. briggsae.
Defined an embryonic muscle module through transitive interactions among transcription factors hlh-1, hnd-1, and unc-120.
Observed that homologous gene interactions are conserved in vertebrate myogenesis, demonstrating that functional modules identified in nematodes reflect broadly conserved genetic programs.

Cite This Study

Baugh et al. (2005) studied this question.

synapsesocial.com/papers/6a720fd3c2d7c30908272912 https://doi.org/10.1186/gb-2005-6-5-r45

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Implication

Genetic screen reveals conserved compensatory transcription factor interactions and a core muscle module in Caenorhabditis elegans embryos, suggesting evolutionary conservation of embryonic gene...

Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions

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Implication

Key Points

Cite This Study

Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions

Discussion

Member takes

Implication

Key Points

Cite This Study

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