Population
Drosophila with mutations in 13 genes affecting muscle development
Comparison
Pairwise combinations of mutations in 13 genes vs Single heterozygous mutant controls
Design
Preclinical
Authors
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May inform multigenic cardiomyopathy models; leaves open human relevance.
Genetic interactions between unlinked muscle genes in Drosophila suggest that normal myofibril development requires tightly regulated relative amounts of gene products.
Homyk et al. (1988) studied this question.
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