May 1, 1994GeneticsOpen Access

Recovery of dominant, autosomal flightless mutants of Drosophila melanogaster and identification of a new gene required for normal muscle structure and function.

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Population

Drosophila melanogaster (fruit flies)

Comparison

Recovery of autosomal dominant flightless… vs Wild-type

Design

Preclinical

Authors

Discussion

Hypothesis-generating for sarcomeric muscle genes; extends Drosophila models but leaves open mammalian ortholog roles in cardiomyopathy.

Population

Drosophila melanogaster (fruit flies)

Intervention

Recovery of autosomal dominant flightless mutations

Comparator

Wild-type

Outcome

Identification and characterization of mutations affecting muscle function and developmentsurrogate

Identifies a novel gene, lethal(3)Laker, required for normal muscle structure and function in Drosophila melanogaster.

Cripps et al. (1994) studied this question.

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