March 1, 1986Proceedings of the National Academy of SciencesOpen Access

Mutations of the Drosophila myosin heavy-chain gene: effects on transcription, myosin accumulation, and muscle function.

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Population

Drosophila melanogaster (Canton-S strain and various mutants: Mhc1, Mhc2, Mhc3, Mhc4, Ifm(2)3)

Comparison

Mutations of the myosin heavy-chain gene vs Wild-type (Canton-S strain) flies

Design

Preclinical

Authors

KMKimiko MogamiYamaguchi University POP T O'DonnellUniversity of Vermont SBSanford I. BernsteinSan Diego State University

Discussion

Member takes

Implication

Drosophila MHC findings should not alter clinical practice; they extend dosage-sensitive muscle models but leave human translation open.

Structured PICO

Population

Drosophila melanogaster (Canton-S strain and various mutants: Mhc1, Mhc2, Mhc3, Mhc4, Ifm(2)3)

Intervention

Mutations of the myosin heavy-chain (MHC) gene (0.1-kb deletion or 8-10 kb insertions)

Comparator

Wild-type (Canton-S strain) flies

Outcome

Muscle function (flight ability, myofibril organization), MHC transcription, and MHC protein accumulationsurrogate

The Drosophila MHC gene is essential for both larval and adult muscle development, with indirect flight muscles being particularly sensitive to MHC gene dosage.

Cite This Study

Mogami et al. (1986) studied this question.

synapsesocial.com/papers/6a835856e8367255819bb43b https://doi.org/10.1073/pnas.83.5.1393

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Mutations of the Drosophila myosin heavy-chain gene: effects on transcription, myosin accumulation, and muscle function.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mutations of the Drosophila myosin heavy-chain gene: effects on transcription, myosin accumulation, and muscle function.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider