August 1, 1998Journal of Biological ChemistryOpen Access

The Raf-MEK-ERK Cascade Represents a Common Pathway for Alteration of Intracellular Calcium by Ras and Protein Kinase C in Cardiac Myocytes

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Structured PICO

Population

Cardiac myocytes

Intervention

Transfection with constitutively active Ras (Ha-RasV12), Ha-RasV12S35, constitutively active Raf, or treatment with PKC-activating phorbol ester (phorbol 12-myristate 13-acetate), with or without cotransfection with dnMEK or SERCA2 overexpression

Comparator

Ha-RasV12C40 (Ras mutant activating PI3K pathway) or baseline/untransfected state

Outcome

Intracellular calcium ([Ca2+]i) transients (magnitude and decay phase)surrogate

The Raf-MEK-ERK cascade represents a common pathway by which Ras and PKC regulate intracellular calcium in cardiac myocytes, potentially contributing to the pathophysiology of cardiac hypertrophy.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May link Ras/PKC-MEK-ERK to myocyte Ca2+ dysregulation; hypothesis-generating for hypertrophy, no clinical implications yet.

Cite This Study

Ho et al. (1998) studied this question.

synapsesocial.com/papers/6a7210a9439bab0cabc3c0b0 https://doi.org/10.1074/jbc.273.34.21730

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The Raf-MEK-ERK Cascade Represents a Common Pathway for Alteration of Intracellular Calcium by Ras and Protein Kinase C in Cardiac Myocytes

Structured PICO

Discussion

Implication

Cite This Study

The Raf-MEK-ERK Cascade Represents a Common Pathway for Alteration of Intracellular Calcium by Ras and Protein Kinase C in Cardiac Myocytes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider