February 16, 2010Hypertension

C-Reactive Protein Promotes Cardiac Fibrosis and Inflammation in Angiotensin II–Induced Hypertensive Cardiac Disease

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Population

Mice expressing human C-reactive protein (CRP) and wild-type mice; in vitro cardiac fibroblasts

Comparison

Chronic infusion of angiotensin II (Ang II) vs Wild-type mice receiving chronic infusion of…

Design

Preclinical

Authors

RZRongxin ZhangMinistry of Education of the People's Republic of China YZYuan Yuan ZhangBeijing Technology and Business University XHXiao Ru HuangHuaihua University

Discussion

Member takes

Implication

No change to hypertension care indicated; leaves open whether CRP inhibition attenuates remodeling in human disease.

Structured PICO

Population

Mice expressing human C-reactive protein (CRP) and wild-type mice; in vitro cardiac fibroblasts

Intervention

Chronic infusion of angiotensin II (Ang II)

Comparator

Wild-type mice receiving chronic infusion of angiotensin II

Outcome

Cardiac remodeling (left ventricular ejection fraction, fractional shortening, cardiac fibrosis, and inflammation)surrogate

CRP acts as a direct mediator in Ang II-induced hypertensive cardiac remodeling, promoting fibrosis and inflammation through upregulation of the AT1 receptor and activation of TGF-beta/Smad and NF-kappaB pathways.

Cite This Study

Zhang et al. (2010) studied this question.

synapsesocial.com/papers/6a7213df35aa2c282ce31378 https://doi.org/10.1161/hypertensionaha.109.140608

Topics

Hypertension management

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C-Reactive Protein Promotes Cardiac Fibrosis and Inflammation in Angiotensin II–Induced Hypertensive Cardiac Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

C-Reactive Protein Promotes Cardiac Fibrosis and Inflammation in Angiotensin II–Induced Hypertensive Cardiac Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider