This narrative review highlights the role of autonomic nervous system dysfunction in contributing to intradialytic blood pressure instability in patients with end-stage kidney disease.
ANS dysfunction may contribute to BP instability in dialysis; leaves open targeted mechanistic and therapeutic research in ESKD.
The autonomic nervous system (ANS) is the principal endogenous defense mechanism that maintains blood pressure in the setting of hypotension. Disruption of the ANS impairs this ability and can contribute to blood pressure instability, including hypotension and hypertension. In this narrative review, we provide an overview of the ANS and the consequences of its dysfunction in patients with end-stage kidney disease treated with dialysis. We also discuss possible mechanisms of this autonomic dysfunction that may need future investigation.
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Shafi et al. (2017) studied this question.
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