Why the study?
Does autonomic nervous system dysfunction explain the occurrence of dialysis hypotension in hemodialysis patients?
Population
16 consecutive hemodialysis patients (5 with a history of dialysis-induced hypotension, 11 without)
Comparison
Physiological testing including isoproterenol… vs Age-matched controls and internal comparison
Design
Cross-sectional
Authors
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Reduced heart period variation signals parasympathetic dysfunction in dialysis patients; does not support autonomic dysfunction as cause of hypotension and leaves mechanisms open.
Does autonomic nervous system dysfunction explain the occurrence of dialysis hypotension in hemodialysis patients?
Autonomic nervous system dysfunction in hemodialysis patients involves the cardiac efferent parasympathetic pathway but does not appear to explain the occurrence of dialysis hypotension.
Nakashima et al. (2008) studied this question.
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