Key result
Intradialytic hypotension in hemodialysis patients was associated with a significant decrease in systemic vascular resistance (-14.0% vs +9.9%, p=0.004) but not with basal autonomic function.
Why the study?
Is intradialytic hypotension related to pre-existent autonomic dysfunction in hemodialysis patients?
Population
28 patients on chronic intermittent hemodialysis
Comparison
Intradialytic hypotension (observational grouping) vs Stable hemodynamics during dialysis
Design
Cohort
Authors
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Intradialytic hypotension links to SVR reduction independent of basal autonomic function; hypothesis-generating and should not yet change clinical assessment in hemodialysis.
Observational (n=28)
Is intradialytic hypotension related to pre-existent autonomic dysfunction in hemodialysis patients?
Absolute Event Rate: -14% vs 9.9%
p-value: p=0.004
Hypotension during hemodialysis is not related to a patient's autonomic function at rest, suggesting structural neuronal differences do not drive the severe decrease in systemic vascular resistance.
Straver et al. (1998) conducted an observational in chronic intermittent haemodialysis (n=28). Intradialytic hypotension vs. Stable hemodynamics during dialysis was evaluated on Change in systemic vascular resistance (p=0.004). Intradialytic hypotension in hemodialysis patients was associated with a significant decrease in systemic vascular resistance (-14.0% vs +9.9%, p=0.004) but not with basal autonomic function.
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