January 1, 1988Nephrology Dialysis Transplantation
Autonomic Nervous System in Haemodialysis
Key result
Terminal chronic renal failure on haemodialysis was associated with lower Valsalva indices, baroreceptor alterations, adrenergic hyperexcitability, and vagal alterations compared to controls.
Why the study?
Does terminal chronic renal failure on haemodialysis cause autonomic neuropathy, and which segments of the autonomic reflex arc are affected?
Population
52 patients with terminal chronic renal failure on haemodialysis, and healthy controls
Comparison
Autonomic nervous system assessment using… vs Healthy control subjects
Design
Cross-sectional
Authors
Discussion
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Implication
May warrant autonomic monitoring in hemodialysis; leaves open causality and segment-specific interventions.
Study Design
Type
Observational (n=60)
Structured PICO
Does terminal chronic renal failure on haemodialysis cause autonomic neuropathy, and which segments of the autonomic reflex arc are affected?
P
Population
52 patients with terminal chronic renal failure on haemodialysis and healthy controls assessed for autonomic neuropathy.
E
Exposure
Autonomic nervous system assessment using Valsalva index, and physiological/pharmacological tests (phenylephrine, hyperventilation, cold pressor, atropine, tyramine, and adrenaline)
C
Comparator
Healthy control subjects
O
Outcome
Existence and location of autonomic neuropathy (assessed via Valsalva index, heart rate, and intraarterial pressure)surrogate
Patients with terminal chronic renal failure on haemodialysis exhibit autonomic neuropathy characterized by baroreceptor dysfunction, vagal impairment, and sympathetic hyperexcitability.
Cite This Study
Bondia et al. (1988) conducted an observational in Terminal chronic renal failure (n=60). Terminal chronic renal failure on haemodialysis vs. Healthy controls was evaluated on Valsalva index and autonomic reflex responses. Terminal chronic renal failure on haemodialysis was associated with lower Valsalva indices, baroreceptor alterations, adrenergic hyperexcitability, and vagal alterations compared to controls.