Why the study?
Emerging equine-like G3P[8] DS-1-like rotavirus strains reported worldwide raised concern, prompting genomic characterization to recognize the genetic diversity of RVA circulating among infants in Colombia.
First report of the novel equine-like G3P[8] rotavirus with a Wa-like backbone in Colombia, highlighting the need for surveillance of emerging viruses.
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Equine-like G3P[8] rotavirus characterization leaves open clinical impact; extends molecular surveillance without practice change.
family, which comprises 11 segments of double-stranded RNA (dsRNA) as a genomic constellation that encodes for six structural and five to six nonstructural proteins. RVA has been classified in a binary system with Gx[Px] based on the spike protein (VP4) and the major outer capsid glycoprotein (VP7), respectively. The emerging equine-like G3P[8] DS-1-like strains reported worldwide in humans have arisen an important concern. Here, we carry out the complete genome characterization of a previously reported G3P[8] strain in order to recognize the genetic diversity of RVA circulating among infants in Colombia. A near-full genome phylogenetic analysis was done, confirming the presence of the novel equine-like G3P[8] with a Wa-like backbone for the first time in Colombia. This study demonstrated the importance of surveillance of emerging viruses in the Colombian population; furthermore, additional studies must focus on the understanding of the spread and transmission dynamic of this important RVA strain in different areas of the country.
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Martínez‐Gutierrez et al. (2021) studied this question.
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