Why the study?
Does the formation of PKCε-Lck signaling modules mediate cardioprotection against ischemic injury in mice?
Population
Wild-type, PKCε transgenic, Lck-/-, and PKCε-Lck-/- double mutant mice and in vitro recombinant…
Comparison
Cardiac-specific transgenic activation of PKCε… vs Wild-type mice, non-preconditioned mice, or…
Design
Preclinical
Follow-up
4-hour reperfusion
Authors
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PKCε cardioprotection requires Lck in mice; hypothesis-generating for a novel target, with no clinical implications yet.
Does the formation of PKCε-Lck signaling modules mediate cardioprotection against ischemic injury in mice?
The assembly of the PKCε-Lck signaling module is an obligatory step in signal transduction for cardioprotection against ischemic injury, presenting a novel therapeutic target.
Ping et al. (2002) studied this question.
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