Why the study?
Does Angiotensin IV induce renal vasoconstriction and pressor responses via specific receptors in mice?
Does Angiotensin IV induce renal vasoconstriction and pressor responses via specific receptors in mice?
Angiotensin IV mediates pressor and renal vasoconstrictor effects in mice primarily via AT1a receptors, rather than the IRAP/AT4 receptor.
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Ang IV effects via AT1a in mice warrant caution extrapolating to humans; leaves open receptor targets for translational hypertension research.
Yang et al. (2010) studied this question.
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