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July 1, 1994Journal of Clinical InvestigationOpen Access

Renin and renin mRNA in proximal tubules of the rat kidney.

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Why the study?

Does converting enzyme inhibition affect proximal tubule renin gene expression in rat kidneys?

Population

Rat kidneys

Comparison

Converting enzyme inhibition (CEI) vs Control (implied)

Design

Preclinical

Authors

MCMiner ChenDonghua UniversityMHMansel HarrisUniversity of VirginiaDRDavid P. RoseWest Virginia University

Discussion

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Implication

Differential renin regulation by CEI in rat kidney compartments suggests distinct signals; leaves open human relevance and therapeutic targeting.

Structured PICO

Does converting enzyme inhibition affect proximal tubule renin gene expression in rat kidneys?

P
Population
Rat kidneys (isolated proximal convoluted tubules, proximal straight tubules, outer medullary collecting ducts, and glomeruli)
I
Intervention
Converting enzyme inhibition (CEI)
C
Comparator
Control (implied)
O
Outcome
Renin enzymatic activity and renin mRNA levelssurrogate

Renin synthesis in the proximal tubule appears to be controlled by different intracellular signals than in the vascular compartment, as it is not stimulated by converting enzyme inhibition.

Cite This Study

Chen et al. (1994) studied this question.

synapsesocial.com/papers/6a721c6dabc331a85807b5e2https://doi.org/10.1172/jci117312
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis by immunocytochemistry and in situ hybridization of renin and its mRNA in kidney, testis, adrenal, and pituitary of the rat.1986 · 253 citations
  2. 2Distribution of Exogenously Administered Renin in Mouse Kidney1982 · 6 citations
  3. 3Direct Radioimmunoassay and Immunocytochemical Localization of Renin in Human Kidneys1979 · 12 citations
  4. 4A Comparative Study of the Distributions of Renin and Angiotensinogen Messenger Ribonucleic Acids in Rat and Mouse Tissues*1987 · 262 citations
  5. 5Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat.1990 · 425 citations