Key result
Endothelin-1 production and mRNA expression are localized to glomeruli and inner medullary collecting ducts in rat nephron segments, and are stimulated by fetal calf serum and TGF-β.
Population
Rat nephron segments (tubule suspensions and microdissected nephron segments)
Design
Preclinical
Authors
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No immediate clinical implications from rat in vitro data; leaves open ET-1 regulation by TGF-β in renal disease.
The study demonstrates that endothelin-1 is produced locally in specific rat nephron segments (glomeruli and IMCD), acting as an autocrine factor.
Ujiie et al. (1992) studied this question. Fetal calf serum (FCS) and Transforming growth factor-beta (TGF-β) vs. Unstimulated segments or other nephron segments was evaluated on Endothelin-1 (ET-1) production and mRNA expression. Endothelin-1 production and mRNA expression are localized to glomeruli and inner medullary collecting ducts in rat nephron segments, and are stimulated by fetal calf serum and TGF-β.
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