November 1, 2001Journal of the American Society of Nephrology
Renal Endothelin-1 and Endothelin Receptor Type B Expression in Glomerular Diseases with Proteinuria
Population
26 patients with different renal diseases, 9 control subjects, and a separate cohort of 16 patients with IgA…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
ET-R(B) upregulation was associated with proteinuria severity; hypothesis-generating for endothelin targeting but should not yet change practice.
Structured PICO
P
Population
26 patients with different renal diseases (10 with proteinuria ≥2 g/24 h, 8 with proteinuria <2 g/24 h), 9 control subjects, and a separate cohort of 16 patients with IgA nephropathy.
C
Comparator
Patients with lower-grade proteinuria (<2 g/24 h) and control subjects
O
Outcome
Expression of ET-1, ET-R(A), and ET-R(B) mRNA and protein in renal biopsiessurrogate
Increased ET-1 and ET-R(B) expression is associated with high-grade proteinuria in human renal disease, and this expression is attenuated by ACE inhibitors.
Cite This Study
Lehrke et al. (2001) studied this question.