What question did this study set out to answer?

The aim is to explore the possibility of standardizing APTT heparin monitoring using various candidate reference reagents.

January 1, 1995Thrombosis and Haemostasis

The APTT Monitoring of Heparin - The ISTH/ICSH Collaborative Study

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Why the study?

Can APTT heparin monitoring be standardized using reference APTT reagents and orthogonal regression analysis?

Population

Lyophilized plasmas containing heparin added in vitro and fresh plasmas from heparinized patients

Comparison

Three candidate reference APTT reagents vs Local APTT reagent

Design

Other

Authors

LPL. PollerCross-Cutting Cardiology EVE. A. van der VeldeLeiden University

Discussion

Member takes

Implication

Local calibration remains essential for APTT heparin monitoring; leaves open whether reference reagents enable safe standardized therapeutic ranges.

Key Points

The aim is to explore the possibility of standardizing APTT heparin monitoring using various candidate reference reagents.
International collaborative study testing three candidate reference APTT reagents with lyophilized and fresh plasmas from heparinized patients.
Calibrated APTT responses using APTT responses of patients with thrombosis and healthy controls.
Used orthogonal regression to determine calibration constant for local APTT systems.
Two candidate reagents performed well; one is recommended as the reference preparation.
Local calibration is necessary for each laboratory instead of a universal calibration constant.
The proposed approach could aid in establishing standardized therapeutic ranges for APTT monitoring.

Structured PICO

Can APTT heparin monitoring be standardized using reference APTT reagents and orthogonal regression analysis?

Population

Lyophilized plasmas containing heparin added in vitro and fresh plasmas from heparinized patients (including patients with thrombosis and normal plasmas)

Intervention

Three candidate reference APTT reagents

Comparator

Local APTT reagent

Outcome

Standardization of APTT heparin monitoring (determination of calibration constant b)surrogate

The adoption of a reference APTT reagent and orthogonal regression analysis is recommended to standardize APTT heparin monitoring and develop safe local therapeutic ranges.

Limitations

Calibration was based on relatively limited numbers of patients' plasmas

Cite This Study

Poller et al. (1995) studied this question.

synapsesocial.com/papers/6a721cd975498292b70b586a https://doi.org/10.1055/s-0038-1653728

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Implication

Local calibration remains essential for APTT heparin monitoring; leaves open whether reference reagents enable safe standardized therapeutic ranges.

The APTT Monitoring of Heparin - The ISTH/ICSH Collaborative Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

The APTT Monitoring of Heparin - The ISTH/ICSH Collaborative Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider