What question did this study set out to answer?

To evaluate the efficacy and underlying immune mechanisms of targeted B cell depletion in preventing and reversing autoimmune diabetes.

December 3, 2007Journal of Clinical InvestigationOpen Access

Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice

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Authors

CHChangyun HuKing's College London DRDaniel Rodríguez‐PintoUniversidad Técnica Particular de Loja WDWei DuSoutheast University

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Implication

Experimental study reveals that CD20-directed B cell depletion reverses established diabetes in transgenic mice, suggesting therapeutic remission via regulatory T and B cell expansion.

Key Points

To evaluate the efficacy and underlying immune mechanisms of targeted B cell depletion in preventing and reversing autoimmune diabetes.
Generated transgenic non-obese diabetic (NOD) mice expressing human CD20 (hCD20) on B cells.
Administered a single treatment cycle of hCD20-specific monoclonal antibody to deplete B cells during pre-diabetic or overtly hyperglycemic disease stages.
Transient B cell depletion significantly delayed or reduced diabetes onset when administered prior to disease manifestation.
Treatment reversed established disease with clinical hyperglycemia in over one-third of diabetic mice.
Disease remission was mediated by the expansion of protective regulatory T cells (Tregs) and regulatory B cells.

Cite This Study

Hu et al. (2007) studied this question.

synapsesocial.com/papers/6a721d42b5c1fe5ca9dff22f https://doi.org/10.1172/jci32405

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Implication

Experimental study reveals that CD20-directed B cell depletion reverses established diabetes in transgenic mice, suggesting therapeutic remission via regulatory T and B cell expansion.

Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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