Population
Murine cardiac myocytes from mature and developing ventricle, and fetal mouse ventricular myocytes
Comparison
Overexpression of full-length and truncated… vs Baseline/control conditions (e.g., normal serum)
Design
Preclinical
Authors
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Nuclear CCt signaling may autoregulate CaV1.2 expression; leaves open its in vivo role or therapeutic targeting.
The C-terminus of the cardiac L-type calcium channel acts as a mobile signaling segment that translocates to the nucleus to autoregulate its own transcription.
Schroder et al. (2009) studied this question.
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