Population
Single adult guinea pig ventricular cells
Comparison
Intracellular ATP and alpha 1-adrenergic agonism… vs Cells without ATP, or without pertussis toxin…
Design
Preclinical
Authors
Loading...
Supports Gi-independent alpha1-adrenergic regulation of cardiac calcium channels in vitro; leaves open relevance to human electrophysiology or clinical interventions.
The cardiac L-type calcium channel is regulated by a pertussis toxin-sensitive substrate (presumably Gi), ATP, and an alpha 1-adrenergic receptor not coupled to Gi.
Keung et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: