Hypercoagulability Is a Stronger Risk Factor for Ischaemic Stroke than for Myocardial Infarction: A Systematic Review
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Why the study?
Does hypercoagulability have a stronger effect on the risk of ischaemic stroke compared to myocardial infarction?
Population
31 study populations reporting the effect of prothrombotic factors on both myocardial infarction and…
Design
Systematic_review
Authors
Discussion
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Implication
Hypercoagulability confers greater IS than MI risk; extends evidence of heterogeneous arterial thrombosis mechanisms for targeted prevention trials.
Structured PICO
Does hypercoagulability have a stronger effect on the risk of ischaemic stroke compared to myocardial infarction?
P
Population
31 study populations (from 70 publications) reporting the effect of prothrombotic factors on both myocardial infarction (MI) and ischaemic stroke (IS) separately.
I
Intervention
351 markers of hypercoagulability (including pro-coagulant, anti-coagulant, fibrinolysis, and platelet function factors).
O
Outcome
Ratio of relative risks (RRR = RRIS/RRMI) comparing the effect of a risk factor on ischaemic stroke versus myocardial infarction.hard clinical
Hypercoagulability appears to be a stronger risk factor for ischaemic stroke than for myocardial infarction, particularly among young individuals and for pro-coagulant factors.
Limitations
- Lack of a standard measure of precision of the RRR estimates (used sum of variances, which is likely an overestimation)
- Unable to adjust estimates for the presence of specific subgroup factors like atrial fibrillation
Cite This Study
Maino et al. (2015) studied this question.
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