A System-Wide Investigation and Stratification of the Hemostatic Proteome in Premature Myocardial Infarction
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Why the study?
While fibrinogen levels are a recognized risk factor for MI, the association of thrombotic risk with other coagulation proteins is inconsistent, likely due to the complex individual balance of pro- and anticoagulant factors.
Population
162 patients with MI at <50 y and 186 age- and gender-matched healthy controls
Comparison
Premature MI patients vs healthy controls with no CAD history
Design
Case-control study with mathematical modeling
Authors
Discussion
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Implication
Coagulation imbalances may aid premature MI risk stratification; hypothesis-generating for prospective validation.
Structured PICO
P
Population
348 subjects, comprising 162 patients who suffered a premature myocardial infarction (MI <50 years, mean age 47.5, 86% male) and 186 age- and gender-matched healthy controls with no history of cardiovascular disease. All subjects were Caucasian of Northern European origin from the UK.
O
Outcome
Measured levels of pro- and anticoagulant proteins in plasma and time-dependent predictions of hemostatic response (thrombin generation) using a mathematical modelsurrogate
Mathematical modeling of the hemostatic proteome reveals distinct procoagulant profiles in patients with premature MI compared to healthy controls, highlighting potential new avenues for risk stratification.
Cite This Study
Dunster et al. (2022) studied this question.
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