Key result
Plasma levels of tissue factor activity, thrombomodulin activity, and procoagulant phospholipid were significantly higher in acute myocardial infarction patients than in healthy controls (P<0.001).
Why the study?
Do plasma levels of TFa, TMa, and procoagulant phospholipid predict unfavourable outcomes in patients with acute myocardial infarction?
Case-Control (n=80)
Do plasma levels of TFa, TMa, and procoagulant phospholipid predict unfavourable outcomes in patients with acute myocardial infarction?
p-value: p=< 0.001
Elevated activity of tissue factor, thrombomodulin, and procoagulant phospholipids during the acute phase of myocardial infarction may serve as prognostic markers for unfavourable outcomes.
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Highlights prothrombotic state in acute MI; leaves open prognostic value for outcomes.
Dreden et al. (2009) conducted a case-control in acute myocardial infarction (n=80). Plasma tissue factor activity, thrombomodulin activity, and procoagulant phospholipid vs. Healthy normal volunteers was evaluated on Plasma levels of TFa, TMa, and procoagulant phospholipid (p=< 0.001). Plasma levels of tissue factor activity, thrombomodulin activity, and procoagulant phospholipid were significantly higher in acute myocardial infarction patients than in healthy controls (P<0.001).
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