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January 1, 1998Thrombosis and Haemostasis

Elevated Tissue Factor and Tissue Factor Pathway Inhibitor Circulating Levels in Ischaemic Heart Disease Patients

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Why the study?

Are circulating levels of Tissue Factor and Tissue Factor Pathway Inhibitor elevated in patients with Ischaemic Heart Disease compared to healthy volunteers?

Population

103 subjects total: 55 patients with Ischaemic Heart Disease not on heparin and 48 sex- and age-matched…

Design

Case-control

Authors

AGAnna Maria GoriVascular MedicineSFSandra FediUniversity of FlorenceLCL. ChiarugiAzienda Ospedaliero-Universitaria Careggi

Discussion

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Implication

Elevated TF/TFPI levels associate with IHD; hypothesis-generating for prognostic or therapeutic roles.

Key Points

  • To evaluate circulating levels of tissue factor (TF), tissue factor pathway inhibitor (TFPI), and active thrombin generation markers in patients with ischaemic heart disease.
  • Assessed 55 IHD patients not taking heparin (18 with unstable angina, 24 with effort angina, and 13 with previous myocardial infarction) alongside 48 sex- and age-matched healthy control subjects.
  • Measured plasma concentrations of TF, TFPI, prothrombin fragment 1-2 (F1+2), and thrombin-antithrombin complexes (TAT).
  • Plasma TF and TFPI were significantly higher in IHD patients (TF median 215.4 pg/ml vs 142.5 pg/ml; TFPI median 129.0 ng/ml vs 60.4 ng/ml; both p<0.001) compared with controls, with highest concentrations observed in unstable angina (TF median 255.6 pg/ml; TFPI median 137.7 ng/ml).
  • TF levels correlated positively with TFPI (r = 0.57, p<0.001), and thrombin generation markers TAT (median 5.2 vs 2.3 µg/l, p<0.001) and F1+2 (median 1.4 vs 0.7 nmol/l, p<0.001) were significantly elevated in IHD patients relative to controls.

Structured PICO

Are circulating levels of Tissue Factor and Tissue Factor Pathway Inhibitor elevated in patients with Ischaemic Heart Disease compared to healthy volunteers?

P
Population
103 subjects total: 55 patients with Ischaemic Heart Disease (IHD) not on heparin (18 with unstable angina, 24 with effort angina, and 13 with previous myocardial infarction) and 48 sex- and age-matched healthy volunteers.
C
Comparator
48 sex- and age-matched healthy volunteers
O
Outcome
Plasma levels of Tissue Factor (TF) and Tissue Factor Pathway Inhibitor (TFPI)surrogate

Patients with ischaemic heart disease exhibit significantly elevated circulating levels of Tissue Factor and Tissue Factor Pathway Inhibitor, indicating active blood clotting activation.

Cite This Study

Gori et al. (1998) studied this question.

synapsesocial.com/papers/6a72738b8031ec7bb1dd5ee9https://doi.org/10.1055/s-0037-1614932

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tissue Factor and Homocysteine Levels in Ischemic Heart Disease Are Associated with Angiographically Documented Clinical Recurrences after Coronary Angioplasty2000 · 46 citations
  2. 2Increased tissue factor pathway inhibitor in patients with acute myocardial infarction1997 · 48 citations
  3. 3The Role of Tissue Factor in the Pathogenesis of Thrombosis and Atherosclerosis1998 · 24 citations
  4. 4Coagulation activation in young survivors of myocardial infarction (MI) - a population-based case-control study2004 · 19 citations
  5. 5Heightened Tissue Factor Associated With Tissue Factor Pathway Inhibitor and Prognosis in Patients With Unstable Angina1999 · 195 citations