Heightened Tissue Factor Associated With Tissue Factor Pathway Inhibitor and Prognosis in Patients With Unstable Angina
Key result
High plasma tissue factor levels in patients with unstable angina were associated with an increased need for in-hospital myocardial revascularization compared to low levels (31.8% vs 3.4%).
Why the study?
Do elevated plasma levels of tissue factor and tissue factor pathway inhibitor predict the need for in-hospital revascularization in patients with unstable angina?
Population
162 patients (51 with unstable angina, 56 with stable exertional angina, and 55 with chest pain syndrome)
Comparison
High plasma tissue factor and free tissue factor… vs Low plasma tissue factor and free tissue factor…
Design
Cohort
Follow-up
in-hospital stay
Authors
Discussion
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Implication
May identify higher-risk unstable angina patients; hypothesis-generating for risk stratification and requires prospective validation.
Study Design
Type
Observational (n=162)
Structured PICO
Do elevated plasma levels of tissue factor and tissue factor pathway inhibitor predict the need for in-hospital revascularization in patients with unstable angina?
P
Population
162 patients with unstable angina, stable exertional angina, or chest pain syndrome evaluated for plasma tissue factor levels and in-hospital outcomes.
E
Exposure
High plasma tissue factor (TF) and free tissue factor pathway inhibitor (TFPI) levels
C
Comparator
Low plasma tissue factor (TF) and free tissue factor pathway inhibitor (TFPI) levels
O
Outcome
Need for myocardial revascularization during in-hospital stayhard clinical
Main Result
Absolute Event Rate: 31.8% vs 3.4%
Elevated plasma tissue factor and free tissue factor pathway inhibitor levels are associated with an increased risk of requiring in-hospital revascularization in patients with unstable angina.
Cite This Study
Soejima et al. (1999) conducted an observational in Unstable angina (n=162). High plasma tissue factor (TF) levels vs. Low plasma tissue factor (TF) levels was evaluated on Requirement for myocardial revascularization during in-hospital stay. High plasma tissue factor levels in patients with unstable angina were associated with an increased need for in-hospital myocardial revascularization compared to low levels (31.8% vs 3.4%).