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July 1, 1997American Journal of HematologyOpen Access

Increased tissue factor pathway inhibitor in patients with acute myocardial infarction

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Why the study?

Are plasma levels of tissue factor pathway inhibitor (TFPI) increased in patients with acute myocardial infarction compared to other thrombotic conditions and healthy volunteers?

Population

23 patients with acute myocardial infarction, 10 with pulmonary embolism, 10 with deep vein thrombosis, and…

Comparison

Percutaneous transluminal coronary angioplasty… vs Healthy volunteers, PE patients, and DVT patients

Design

Cohort

Follow-up

24 hours post-PTCA

Authors

YKYuko KamikuraMie UniversityHWHideo WadaOsaka Institute of TechnologyAYAtsushi YamadaMie University

Discussion

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Implication

TFPI elevation associates with AMI versus other thromboses; leaves open its diagnostic or prognostic utility pending prospective validation.

Structured PICO

Are plasma levels of tissue factor pathway inhibitor (TFPI) increased in patients with acute myocardial infarction compared to other thrombotic conditions and healthy volunteers?

P
Population
23 patients with acute myocardial infarction (AMI), 10 with pulmonary embolism (PE), 10 with deep vein thrombosis (DVT), and healthy volunteers
I
Intervention
Percutaneous transluminal coronary angioplasty (PTCA) in the AMI group
C
Comparator
Healthy volunteers, PE patients, and DVT patients
O
Outcome
Plasma levels of total tissue factor pathway inhibitor (TFPI) and free-TFPIsurrogate

TFPI levels are significantly elevated in AMI compared to other thrombotic conditions and transiently increase further following PTCA, suggesting release from ischemic tissues.

Cite This Study

Kamikura et al. (1997) studied this question.

synapsesocial.com/papers/6a6f7819fe4101aa97dfcb01https://doi.org/10.1002/(sici)1096-8652(199707)55:4<183::aid-ajh3>3.0.co;2-o

Topics

Pulmonary embolism
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma and Platelet Plasminogen Activator Inhibitor-1 in Patients With Acute Myocardial Infarction2000 · 13 citations
  2. 2Tissue factor pathway inhibitor on circulating microparticles in acute myocardial infarction2004 · 94 citations
  3. 3Decreased protein C inhibitor after percutaneous transluminal coronary angioplasty in patients with acute myocardial infarction1995 · 28 citations
  4. 4Plasma levels of tissue plasminogen activator-inhibitor complex (t-PAIC) in patients with acute myocardial Infarction: An observational study2024
  5. 5Depression of Tissue Plasminogen Activator (t-PA) Activity and Rise of t-PA Inhibition and Acute Phase Reactants in Blood of Patients with Acute Myocardial Infarction (AMI)1987 · 51 citations