Key result
Prior myocardial infarction in young survivors was associated with significantly increased thrombin-antithrombin complex levels (8.2 vs 3.9 microg/l, p=0.01) compared to controls.
Population
62 patients with verified myocardial infarction, 40-60 years of age, examined 1-4 years after the acute…
Design
Case-control
Authors
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May indicate persistent prothrombotic state in young MI survivors; leaves open whether this warrants targeted antithrombotic strategies pending prospective validation.
Case-Control
Absolute Event Rate: 8.2% vs 3.9%
p-value: p=0.01
Young survivors of myocardial infarction exhibit an apparent increase in basal activation of the coagulation system 1-4 years post-event, accompanied by decreased FVIIa and increased free TFPI antigen.
Børvik et al. (2004) conducted a case-control in Myocardial infarction. Prior myocardial infarction vs. Control subjects was evaluated on Thrombin-antithrombin complex (TAT) levels (microg/l) (p=0.01). Prior myocardial infarction in young survivors was associated with significantly increased thrombin-antithrombin complex levels (8.2 vs 3.9 microg/l, p=0.01) compared to controls.
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