Why the study?
Carbon ion and proton beam radiation deliver most energy to target tissues unlike x-ray therapy used for refractory ventricular tachyarrhythmias, but their electrophysiological and pathological cardiac effects needed investigation.
Does medium-dose external carbon ion and proton beam radiation alter electrophysiological and pathological properties of the left ventricle in a rabbit model?
Does medium-dose external carbon ion and proton beam radiation alter electrophysiological and pathological properties of the left ventricle in a rabbit model?
Medium-dose carbon ion and proton beam radiation induces significant electrophysiological and fibrotic changes in the left ventricle, suggesting a potential mechanism for modifying arrhythmogenic substrates.
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Medium-dose particle radiation induced LV conduction slowing and fibrosis in rabbits; leaves open safe translation to human VT ablation pending dose-optimization trials.
Takami et al. (2021) studied this question.
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