Why the study?
Does neostigmine effectively reverse residual neuromuscular block 1 to 4 hours after a single dose of vecuronium?
Population
60 patients receiving nitrous oxide/isoflurane/fentanyl anesthesia and a single intubating dose of vecuronium
Design
Other
Follow-up
up to 4 hours
Authors
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Caution against neostigmine when TOF ratio >=0.9 to avoid paradoxical decrease; leaves open optimal reversal timing after vecuronium.
Does neostigmine effectively reverse residual neuromuscular block 1 to 4 hours after a single dose of vecuronium?
Neostigmine effectively reverses residual neuromuscular block after vecuronium but can paradoxically decrease TOF ratio if recovery is already near complete, and is associated with a high incidence of adverse cardiovascular effects.
James E. Caldwell (1995) studied this question.
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