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November 1, 1990AnesthesiologyOpen Access

Does Perioperative Tactile Evaluation of the Train-of-four Response Influence the Frequency of Postoperative Residual Neuromuscular Blockade?

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Why the study?

Does perioperative manual evaluation of the train-of-four response reduce the frequency of postoperative residual neuromuscular blockade in patients receiving vecuronium or pancuronium?

Population

80 patients undergoing surgery requiring neuromuscular blockade (vecuronium or pancuronium)

Comparison

Perioperative manual evaluation of the response… vs Evaluation of the degree of neuromuscular…

Design

RCT, Randomized controlled clinical trial

Follow-up

Perioperative and recovery room period

Authors

TPThomas Garm PedersenAalborg UniversityJVJ. Viby‐MogensenCopenhagen University HospitalUBU. BangHvidovre Hospital

Discussion

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Implication

Nerve stimulator use does not reduce residual blockade; challenges routine adoption over clinical evaluation alone.

Structured PICO

Does perioperative manual evaluation of the train-of-four response reduce the frequency of postoperative residual neuromuscular blockade in patients receiving vecuronium or pancuronium?

P
Population
80 patients undergoing surgery requiring neuromuscular blockade (vecuronium or pancuronium)
I
Intervention
Perioperative manual evaluation of the response to train-of-four (TOF) nerve stimulation
C
Comparator
Evaluation of the degree of neuromuscular blockade solely by clinical criteria
O
Outcome
Frequency of postoperative residual neuromuscular blockadesurrogate

Perioperative manual evaluation of TOF response does not appear to reduce the incidence of postoperative residual neuromuscular blockade compared to clinical evaluation alone.

Cite This Study

Pedersen et al. (1990) studied this question.

synapsesocial.com/papers/6a72c2e4ac440176ef2ad8d3https://doi.org/10.1097/00000542-199011000-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of tetanic stimulation prior to train-of-four monitoring on the time to muscle response stabilization with neuromuscular blockade with rocuronium in patients aged 60 to 80 years: A prospective randomized controlled trial2024 · 1 citations
  2. 2Electrical and Mechanical Train-of-Four Responses during Depolarizing and Nondepolarizing Neuromuscular Blockade1986 · 32 citations
  3. 3Postoperative neuromuscular function following non-depolarising muscle blockade in patients at Inkosi Albert Luthuli Central Hospital, Durban2016 · 3 citations
  4. 4Reversal of Residual Neuromuscular Block with Neostigmine at One to Four Hours After a Single Intubating Dose of Vecuronium1995 · 93 citations
  5. 5Assessment of Neuromuscular Blockade Using Acceleromyography Should Be Performed Before Emergence from Anesthesia2005 · 5 citations