January 1, 1997The Journal of PhysiologyOpen Access

Potassium currents in acutely isolated human hippocampal dentate granule cells.

View Full Paper

Ask AI

Bookmark

Population

34 dentate granule cells acutely isolated from the resected hippocampus of 11 patients with…

Design

Preclinical

Authors

HBHeinz BeckGoethe University Frankfurt HCHans ClusmannUniversitätsklinikum Aachen TKThomas KralUniversity of Vienna

Discussion

Member takes

Implication

Characterizes K+ currents in human epileptic dentate granule cells; leaves open their roles in seizure mechanisms or channel-targeted therapies.

Structured PICO

Population

34 dentate granule cells acutely isolated from the resected hippocampus of 11 patients with therapy-refractory temporal lobe epilepsy (TLE)

Intervention

Pharmacological agents (tetraethylammmonium, charybdotoxin, apamin, 4-aminopyridine) and ion substitutions (low-Ca2+, Ba2+, Cd2+)

Outcome

Properties of voltage- and Ca(2+)-dependent K+ currentssurrogate

The study characterizes four distinct types of potassium currents in human hippocampal dentate granule cells from patients with temporal lobe epilepsy.

Cite This Study

Beck et al. (1997) studied this question.

synapsesocial.com/papers/6a7224e0660549caf2c676dd https://doi.org/10.1113/jphysiol.1997.sp021842

View Full Paper

Ask AI

Bookmark

Implication

Characterizes K+ currents in human epileptic dentate granule cells; leaves open their roles in seizure mechanisms or channel-targeted therapies.

Potassium currents in acutely isolated human hippocampal dentate granule cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Potassium currents in acutely isolated human hippocampal dentate granule cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider