Population
Streptozotocin (STZ)-induced type-1 diabetes (T1D) rats and sham rats
Comparison
HCN channel blockers vs Sham rats / baseline without blockers
Design
Preclinical
Authors
Loading...
May implicate HCN channels in T1D baroreflex impairment; leaves open translation to human autonomic neuropathy.
In a rat model of type 1 diabetes, decreased excitability of aortic baroreceptor neurons is mediated by increased expression and activity of HCN channels.
Li et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: