Population
Sham and streptozotocin-induced type 1 diabetic rats (aortic baroreceptor neurons in nodose ganglia)
Comparison
Losartan, apocynin, and tempol vs Sham rats and untreated diabetic rats
Design
Preclinical
Authors
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Supports Ang II-NADPH oxidase pathway as a target in diabetic baroreceptor dysfunction; leaves open translation to human autonomic neuropathy.
Endogenous angiotensin II-NADPH oxidase-superoxide signaling contributes to depressed cell excitation in aortic baroreceptor neurons of diabetic rats, which can be reversed by AT1R blockade or antioxidants.
Li et al. (2011) studied this question.
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