Why the study?
Does local inhibition of Ang II-NADPH oxidase-superoxide signaling improve arterial baroreflex sensitivity in STZ-induced diabetic rats?
Population
Male Sprague-Dawley rats (200-220 g) with streptozotocin (STZ)-induced diabetes
Comparison
Local microinjection of losartan, apocynin, or… vs Sham rats and diabetic rats without the specific…
Design
Preclinical, Rats were randomly assigned to sham and diabetic rats.
Follow-up
6-8 weeks after STZ injection
Authors
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Should not alter clinical practice; hypothesis-generating for nodose ganglia Ang II pathway targeting in diabetic autonomic dysfunction.
Does local inhibition of Ang II-NADPH oxidase-superoxide signaling improve arterial baroreflex sensitivity in STZ-induced diabetic rats?
Overactivation of the Ang II-NADPH oxidase-superoxide signal pathway in the nodose ganglia contributes to blunted baroreflex sensitivity in diabetes, presenting a potential pharmacological target.
Yulong Li (2011) studied this question.
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