May 1, 1993Circulation ResearchOpen Access

Selective contribution of two types of carotid sinus baroreceptors to the control of blood pressure.

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Population

Dogs (preclinical model)

Comparison

Selective elimination of afferent input from… vs Unblocked baseline state

Design

Preclinical

Authors

JSJ. L. SeagardMedical College of Wisconsin FHF. A. HoppMedical College of Wisconsin HDHeather A. DrummondUniversity of Mississippi Medical Center

Discussion

Member takes

Implication

Differential fiber contributions to baroreflex sensitivity versus tonic BP in animals leave open selective neuromodulation strategies for human hypertension.

Structured PICO

Population

Dogs (preclinical model)

Intervention

Selective elimination of afferent input from carotid sinus baroreceptors using anodal block (large A-fibers) or bupivacaine block (small A-fibers and C-fibers)

Comparator

Unblocked baseline state

Outcome

Tonic baseline blood pressure and dynamic baroreflex sensitivitysurrogate

Large A-fiber baroreceptors primarily regulate dynamic baroreflex sensitivity, while smaller A-fiber and unmyelinated C-fiber baroreceptors primarily control tonic baseline blood pressure.

Cite This Study

Seagard et al. (1993) studied this question.

synapsesocial.com/papers/6a72254122b3175134db6fb7 https://doi.org/10.1161/01.res.72.5.1011

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Implication

Differential fiber contributions to baroreflex sensitivity versus tonic BP in animals leave open selective neuromodulation strategies for human hypertension.

Selective contribution of two types of carotid sinus baroreceptors to the control of blood pressure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Selective contribution of two types of carotid sinus baroreceptors to the control of blood pressure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider