Population
Thiopental-anesthetized dogs (25 mg/kg, plus 10 mg/kg/hr) with vascularly isolated carotid sinus preparations
Design
Preclinical
Authors
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Distinguishes dynamic versus tonic baroreceptor signaling in animals; leaves open translation to human BP regulation.
Carotid sinus baroreceptors exhibit two distinct firing patterns (type I and type II) corresponding to different fiber types, suggesting specialized roles in sensing dynamic versus baseline arterial blood pressure.
Seagard et al. (1990) studied this question.
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