Why the study?
Does pretreatment with angiotensin II AT1 receptor antagonists reduce infarct area and improve cerebral blood flow in spontaneously hypertensive rats undergoing MCA occlusion?
Does pretreatment with angiotensin II AT1 receptor antagonists reduce infarct area and improve cerebral blood flow in spontaneously hypertensive rats undergoing MCA occlusion?
Chronic AT1 receptor blockade with candesartan protects against cerebral ischemia in hypertensive rats by normalizing MCA media thickness and improving cerebral blood flow.
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Does not support clinical use of candesartan pretreatment in stroke; hypothesis-generating for AT1 blockade effects on cerebral vessels.
Ito et al. (2002) studied this question.
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